APBB1 Antibody

Size

100ul

Clone Number

Aliases

Adaptor protein FE65a2 antibody; Amyloid beta (A4) precursor protein binding family B member 1 antibody; Amyloid beta A4 precursor protein binding family B antibody; Amyloid beta A4 precursor protein binding family B member 1 antibody; Amyloid beta A4 precursor protein-binding family B member 1 antibody; Amyloid beta precursor protein binding family B member 1 antibody; APBB 1 antibody; APBB1 antibody; APBB1_HUMAN antibody; FE 65 antibody; Fe65 protein antibody; Protein Fe65 antibody; RIR antibody; stat like protein antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O00213

Immunogen

Recombinant Human Amyloid beta A4 precursor protein-binding family B member 1 protein (361-710AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on \\\'Tyr-142\\\' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

APBB1

Research Areas

Neuroscience; Signal transduction