Apaf-1 Polyclonal Antibody

Ab type

Primary antibody

Background

APAF1 encodes a cytoplasmic protein that initiates apoptosis. Apoptotic protease-activating factor 1 contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human APAF1. AA range:501-550

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

141840

synonyms

APAF1; KIAA0413; Apoptotic protease-activating factor 1; APAF-1