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SKU:DHD68911-1MG
Research Grade Sotigalimab
Research Grade Sotigalimab
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Catalog No.: DHD68911
| Catalog No. | DHD68911 |
|---|---|
| Product name | Research Grade Sotigalimab |
| Size | 1 mg; 5 mg; 25 mg |
| Host species | Humanized |
| Species reactivity | Human |
| Form | Liquid |
| Storage buffer | 0.01M PBS, pH 7.4. |
| Purity | >95% as determined by SDS-PAGE. |
| Clonality | Monoclonal |
| Isotype | IgG1-Kappa |
| Applications | Research Grade Biosimilar |
| Target | Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, TNFRSF5, CDw40, CD40 |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin level | Please contact with the lab for this information. |
| Expression system | Mammalian Cells |
| Accession | P25942 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Alternative Names | APX005M, APX-005, APX-005-M, APX-005M, CAS: 2305607-45-6 |
| Clone ID | Sotigalimab |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
| Description | The FDA has granted an orphan drug designation to sotigalimab (APX005M) as a potential therapeutic option for patients with soft tissue sarcoma, according to announcement from Apexigen Inc., the drug developer. A novel, humanized monoclonal antibody, sotigalimab was designed stimulate antitumor immune response and to target CD40, which is a key co-stimulatory receptor that serves to activate innate and adaptive immune systems. When sotigalimab binds to CD40 on antigen-presenting cells, it induces a multifaceted immune response that brings several components of the immune system together to attack the cancer. |
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