anti- SMAD7 antibody

Host

Rabbit

Uniprot ID

O15105

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Antagonist of signaling by TGF-beta(transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta(Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator(By similarity).

Immunogen

SMAD family member 7

Synonyms

MADH7, MADH8

Observed MW

46 kDa

Reactivity

Human, Mouse

Tested Application

ELISA, WB

Recommended dilution

WB: 1:500-1:2000

Gene ID

4092

Research Area

Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology