anti- SIRT5 antibody

Host

Rabbit

Uniprot ID

Q9NXA8

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins(PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting(PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species(PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2(By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c(CYCS) and a number of other proteins in vitro such as UOX.

Immunogen

sirtuin(silent mating type information regulation 2 homolog) 5

Synonyms

FLJ36950, SIR2 like protein 5, SIR2L5, SIRT5

Observed MW

33 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IP

Recommended dilution

WB: 1:500-1:1000; IP: 1:500-1:1000; IF: 1:50-1:500

Gene ID

Research Area

Epigenetics, Metabolism