anti- SH3BP4 antibody

Host

Rabbit

Uniprot ID

Q9P0V3

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.

Immunogen

SH3-domain binding protein 4

Synonyms

BOG25, EHB10, TTP

Observed MW

120 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IF, IP

Recommended dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200

Gene ID

23677

Research Area

Cancer, Signal Transduction, Metabolism, Developmental biology