anti- SFPQ antibody

Host

Rabbit

Uniprot ID

P23246

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background

SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types. This antibody is a rabbit polyclonal antibody raised against the N-terminal of human SFPQ.

Immunogen

splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)

Synonyms

PSF

Observed MW

115 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC

Recommended dilution

WB: 1:500 - 1:1000; IHC: 1:50 - 1:200

Gene ID

6421

Research Area

Neuroscience, Metabolism