anti- SETD1B antibody

Host

Rabbit

Uniprot ID

Q9UPS6

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase(HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

Immunogen

SET domain containing 1B

Synonyms

KIAA1076, KMT2G, SET1B

Observed MW

260 kDa

Reactivity

Human, Mouse

Tested Application

ELISA, WB, IP, IHC,IF

Recommended dilution

WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500

Gene ID

23067

Research Area

Epigenetics, Metabolism