anti- ROCK2 antibody

Host

Rabbit

Uniprot ID

O75116

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.

Immunogen

Rho-associated, coiled-coil containing protein kinase 2

Synonyms

KIAA0619

Observed MW

161 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC, IF, IP

Recommended dilution

WB: 1:1000-1:10000; IP: 1:200-1:2000;; IHC: 1:20-1:200; IF: 1:10-1:100

Gene ID

9475

Research Area

Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology, Cell Division and Proliferation