anti- RIP3 antibody

Host

Rabbit

Uniprot ID

Q9Y572

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Immunogen

receptor-interacting serine-threonine kinase 3

Synonyms

Receptor interacting protein 3, RIP 3, RIP like protein kinase 3, RIP3, RIPK3

Observed MW

57 kDa

Reactivity

Human, Mouse

Tested Application

ELISA, IP, WB,IHC

Recommended dilution

WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:100-1:400

Gene ID

Research Area

Signal Transduction, Metabolism