anti- REST antibody

Host

Rabbit

Uniprot ID

Q13127

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Transcriptional repressor which binds neuron-restrictive silencer element(NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Immunogen

RE1-silencing transcription factor

Synonyms

NRSF, REST, X2 box repressor, XBR

Observed MW

122 kDa, 200kd

Reactivity

Human, Rat

Tested Application

ELISA, WB, IP

Recommended dilution

WB: 1:500-1:1000; IP: 1:500-1:2000

Gene ID

5978

Research Area

Stem Cells, Metabolism