anti- Renin receptor,ATP6AP2 antibody

Host

Rabbit

Uniprot ID

O75787

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

ATP6AP2, also named as ATP6IP2, CAPER, ELDF10, N14F, ATP6M8-9, Renin receptor and prorenin receptor, is believed to potentiate the renin–angiotensin system(RAS), conferring to prorenin, a likely pathological role at tissue level. The PRR has been identified in the microvascular endothelial cells of the retina, in which it seems to be involved in pathological neovascularization processes. The present study demonstrates for the first time that the PRR is expressed in human ATP6AP2 and suggests a molecular mechanism by which hypertension may exacerbate the pathology of dry AMD.

Immunogen

ATPase, H+ transporting, lysosomal accessory protein 2

Synonyms

APT6M8 9, ATP6AP2, ATP6IP2, ATP6M8 9, CAPER, ELDF10, HT028, M8 9, MRXE, MSTP009, N14F, PRR, PSEC0072, Renin receptor, RENIN RECEPTOR,ATP6AP2, Renin/prorenin receptor, V ATPase M8.9 subunit, XMRE

Observed MW

47kd

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC

Recommended dilution

WB: 1:500-1:1000; IHC: 1:20-1:200

Gene ID

10159

Research Area

Signal Transduction, Metabolism