anti- REDD1 specific antibody

Host

Rabbit

Uniprot ID

Q9NX09

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

REDD1, also named as RTP801 and DDIT4, belongs to the DDIT4 family.Its function：Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1(mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes(By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication(By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.This antibody is specific to the REDD1.

Immunogen

DNA-damage-inducible transcript 4

Synonyms

HIF-1 responsive protein RTP801,Protein regulated in development and DNA damage response 1,REDD-1,REDD1, RTP801,DDIT4

Observed MW

35 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, IHC, IP, WB

Recommended dilution

WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:200

Gene ID

54541

Research Area

Epigenetics, Immunology, Cardiovascular