anti- RBL2 antibody

Host

Rabbit

Uniprot ID

Q08999

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Immunogen

retinoblastoma-like 2(p130)

Synonyms

FLJ26459, P130, pRb2, Rb2, RBL2, RBR 2, retinoblastoma like 2(p130), Retinoblastoma like protein 2

Observed MW

130 kDa

Reactivity

Human

Tested Application

ELISA

Recommended dilution

WB: 1:200-1:2000

Gene ID

5934

Research Area

Metabolism, Immunology, Cancer, Developmental biology, Cell Division and Proliferation