anti- RAD51 antibody

Host

Rabbit

Uniprot ID

Q06609

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange(PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.

Immunogen

RAD51 homolog

Synonyms

RAD51A, RECA

Observed MW

37 kDa

Reactivity

Human, Mouse

Tested Application

ELISA, WB, IP,IHC

Recommended dilution

WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:50-1:500

Gene ID

5888

Research Area

Epigenetics, Cancer, Metabolism, Developmental biology