anti- PTPN22 antibody

Host

Rabbit

Uniprot ID

Q9Y2R2

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Acts as negative regulator of T-cell receptor(TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules(PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue(PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue(PubMed:16461343). Dephosphorylates the immune system activator SKAP2(PubMed:21719704). Positively regulates toll-like receptor(TLR)-induced type 1 interferon production(PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon(By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy(PubMed:23991106).

Immunogen

protein tyrosine phosphatase, non-receptor type 22(lymphoid)

Synonyms

PTPN8

Observed MW

79-95 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC, IP

Recommended dilution

WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

Gene ID

26191

Research Area

Signal Transduction, Metabolism