anti- PTPMT1 antibody

Host

Rabbit

Uniprot ID

Q8WUK0

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate(PGP) to phosphatidylglycerol(PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells(By similarity).

Immunogen

protein tyrosine phosphatase, mitochondrial 1

Synonyms

MOSP, PLIP

Observed MW

21-23 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC

Recommended dilution

WB: 1:200-1:1000; IHC: 1:20-1:200

Gene ID

114971

Research Area

Metabolism