anti- PTGES3 antibody

Host

Rabbit

Uniprot ID

Q15185

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2(PGH2) to prostaglandin E2(PGE2)(PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes(PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway(PubMed:24711448).

Immunogen

prostaglandin E synthase 3(cytosolic)

Synonyms

P23, TEBP

Observed MW

21-23 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, IF, IP, WB, FC

Recommended dilution

WB: 1:500-1:2000; IP: 1:200-1:2000; IF: 1:20-1:200

Gene ID

10728

Research Area

Signal Transduction