anti- PSME3 antibody

Host

Rabbit

Uniprot ID

P61289

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Subunit of the 11S REG-gamma(also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring(PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination-and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition(PubMed:25361978).

Immunogen

proteasome(prosome, macropain) activator subunit 3(PA28 gamma; Ki)

Synonyms

Observed MW

30 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC, IF, IP

Recommended dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200

Gene ID

10197

Research Area

Cancer, Metabolism