anti- PSMD14 antibody

Host

Rabbit

Uniprot ID

O00487

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks(DSBs): acts as a regulator of non-homologous end joining(NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.

Immunogen

proteasome(prosome, macropain) 26S subunit, non-ATPase, 14

Synonyms

PAD1, POH1, PSMD14, rpn11

Observed MW

35 kDa

Reactivity

Human

Tested Application

ELISA, WB, IHC

Recommended dilution

WB: 1:200-1:2000; IHC: 1:20-1:200

Gene ID

10213

Research Area

Metabolism