anti- Prealbumin/transthyretin antibody

Host

Mouse

Uniprot ID

P02766

Form

liquid

Purification

Protein A+G purification

Purity

? 95% as determined by SDS-PAGE

Clonality

monoclonal

Clone ID

80000

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Transthyretin(TTR) is a plasma transport protein for thyroxine and retinol, through the association with retinol-binding protein. It is a homotetrameric protein synthesized mainly in liver, choroid plexus, retinal pigment epithelium, and pancreas.Within the CNS, TTR is the only known protein synthesized solely by the choroid plexus. Mutant and wildtype TTR give rise to various forms of amyloid deposition(amyloidosis). Defects in TTR are the cause of amyloidosis transthyretin-related(AMYL-TTR),hyperthyroxinemia dystransthyretinemic euthyroidal(HTDE) and carpal tunnel syndrome type 1(CTS1). In addition, positive immunostaining for TTR has been reported as a sensitive diagnostic marker of choroid plexus tumors.(22103483)

Immunogen

transthyretin

Synonyms

ATTR, HsT2651, PALB, Prealbumin, TBPA, transthyretin, TTR

Observed MW

16kd

Reactivity

Human

Tested Application

ELISA, WB, IHC

Recommended dilution

WB: 1:500-1:5000; IHC: 1:20-1:200

Gene ID

7276

Research Area

Cancer, Immunology, Signal Transduction