anti- PPARA antibody

Host

Rabbit

Uniprot ID

Q07869

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine(16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

Immunogen

peroxisome proliferator-activated receptor alpha

Synonyms

hPPAR, NR1C1, PPAR, PPAR alpha, PPARA

Observed MW

52-55 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC,IP

Recommended dilution

WB: 1:200-1:1000; IP: 1:200-1:1000 ; IHC: 1:50-1:200

Gene ID

5465

Research Area

Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience