anti- PLEKHA8 antibody

Host

Rabbit

Uniprot ID

Q96JA3

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network(TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide(GlcCer) from the trans-Golgi network(TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate(PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.

Immunogen

pleckstrin homology domain containing, family A(phosphoinositide binding specific) member 8

Synonyms

FAPP2

Observed MW

49 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC

Recommended dilution

WB: 1:500-1:2000; IHC: 1:20-1:200

Gene ID

84725

Research Area

Signal Transduction