anti- PBX1 antibody

Host

Rabbit

Uniprot ID

P40424

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the(1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex(PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression(By similarity).

Immunogen

pre-B-cell leukemia homeobox 1

Synonyms

PRL

Observed MW

52 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IF, IP

Recommended dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200

Gene ID

5087

Research Area

Cancer, Metabolism, Developmental biology