anti- PARN antibody

Host

Rabbit

Uniprot ID

O95453

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen

poly(A)-specific ribonuclease (deadenylation nuclease)

Synonyms

DAN

Observed MW

90 kDa

Reactivity

Human

Tested Application

ELISA, WB, IHC

Recommended dilution

WB: 1:1000 - 1:3000; IHC: 1:50 - 1:200

Gene ID

5073

Research Area

Metabolism