anti- PACSIN1 antibody

Host

Rabbit

Uniprot ID

Q9BY11

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission(By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.

Immunogen

protein kinase C and casein kinase substrate in neurons 1

Synonyms

KIAA1379

Observed MW

48-51 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IF

Recommended dilution

WB: 1:500-1:2000; IF: 1:20-1:200

Gene ID

29993

Research Area

Neuroscience, Signal Transduction, Metabolism