anti- PA2G4 antibody

Host

Mouse

Uniprot ID

Q9UQ80

Form

liquid

Purification

Protein A+G purification

Purity

? 95% as determined by SDS-PAGE

Clonality

monoclonal

Clone ID

5C6

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor(AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin(HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase(HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs(internal ribosomal entry site)(By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation(By similarity).

Immunogen

proliferation-associated 2G4, 38kDa

Synonyms

EBP1

Observed MW

48 kDa

Reactivity

Human

Tested Application

ELISA, WB, IHC, IF

Recommended dilution

WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:20-1:200

Gene ID

5036

Research Area

Cardiovascular, Metabolism