anti- ORAI1 antibody

Host

Mouse

Uniprot ID

Q96D31

Form

liquid

Purification

Protein A+G purification

Purity

? 95% as determined by SDS-PAGE

Clonality

monoclonal

Clone ID

8C0

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Ca(2+) release-activated Ca(2+)(CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT(PubMed:16582901).

Immunogen

ORAI calcium release-activated calcium modulator 1

Synonyms

CRACM1, FLJ14466, ORAI1, ORAI1 L1, ORAI1 L2, Orail L2, ORAT1, Protein orai 1, TMEM142A, Transmembrane protein 142A

Observed MW

32 kDa

Reactivity

Human

Tested Application

ELISA, WB,IHC

Recommended dilution

WB: 1:500-1:2000; IHC: 1:50-1:500

Gene ID

84876

Research Area

Immunology, Signal Transduction