anti- ORAI1 antibody

Host

Rabbit

Uniprot ID

Q96D31

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Ca(2+) release-activated Ca(2+)(CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 . CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT(PubMed:16582901).

Immunogen

ORAI calcium release-activated calcium modulator 1

Synonyms

CRACM1, FLJ14466, ORAI1, ORAI1 L1, ORAI1 L2, Orail L2, ORAT1, Protein orai 1, TMEM142A, Transmembrane protein 142A

Observed MW

45 kDa

Reactivity

Human, Mouse, Rat, Zebrafish

Tested Application

ELISA, WB, IF

Recommended dilution

WB: 1:500-1:1000; IF: 1:10-1:100

Gene ID

84876

Research Area

Immunology, Signal Transduction