anti- NUP85 antibody

Host

Rabbit

Uniprot ID

Q9BW27

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Essential component of the nuclear pore complex(NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade.

Immunogen

nucleoporin 85kDa

Synonyms

NUP75, PCNT1

Observed MW

70-75kd

Reactivity

Human, Mouse

Tested Application

ELISA, WB, IHC, IF

Recommended dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

Gene ID

79902

Research Area

Signal Transduction, Metabolism