anti- NUMB antibody

Host

Mouse

Uniprot ID

P49757

Form

liquid

Purification

Protein A+G purification

Purity

? 95% as determined by SDS-PAGE

Clonality

monoclonal

Clone ID

0

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells(RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone(SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

Immunogen

numb homolog(Drosophila)

Synonyms

Observed MW

68 kDa

Reactivity

Human, Mouse

Tested Application

ELISA, WB, IHC, IF

Recommended dilution

WB: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:20-1:200

Gene ID

8650

Research Area

Signal Transduction, Cardiovascular, Immunology, Developmental biology, Neuroscience, Stem Cells