anti- NRF2, NFE2L2 antibody

Host

Rabbit

Uniprot ID

Q16236

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response(ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress(PMID:14567983).In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance(PMID:20534738). Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC.

Immunogen

nuclear factor(erythroid-derived 2)-like 2

Synonyms

HEBP1, NF E2 related factor 2, NFE2 related factor 2, NFE2L2, NRF2

Observed MW

70-100 kDa

Reactivity

Human, Mouse, Rat, Zebrafish

Tested Application

ELISA, IP, WB, IHC, FC

Recommended dilution

WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:50-1:500

Gene ID

4780

Research Area

Epigenetics, Cancer, Metabolism, Developmental biology