anti- NOTCH3 antibody

Host

Rabbit

Uniprot ID

Q9UM47

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain(NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs(By similarity).

Immunogen

Notch homolog 3

Synonyms

CADASIL, CASIL, Notch 3, Notch homolog 3, NOTCH3

Observed MW

250-260 kDa, 100 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC, IP

Recommended dilution

WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:50-1:500

Gene ID

4854

Research Area

Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology