anti- NGEF antibody

Host

Rabbit

Uniprot ID

Q8N5V2

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Acts as a guanine nucleotide exchange factor(GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension(By similarity).

Immunogen

neuronal guanine nucleotide exchange factor

Synonyms

Observed MW

75 kDa

Reactivity

Human, Mouse

Tested Application

ELISA, WB, IP, IHC

Recommended dilution

WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:50-1:500

Gene ID

25791

Research Area

Developmental biology