anti- NFE2 antibody

Host

Rabbit

Uniprot ID

Q16621

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2(HS2) of the beta-globin control region(LCR). This subunit(NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.

Immunogen

nuclear factor(erythroid-derived 2), 45kDa

Synonyms

Observed MW

45 kDa

Reactivity

Human

Tested Application

ELISA, WB, IHC, IF, IP

Recommended dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200

Gene ID

4778

Research Area

Metabolism, Developmental biology