anti- NENF antibody

Host

Mouse

Uniprot ID

Q9UMX5

Form

liquid

Purification

Protein A+G purification

Purity

? 95% as determined by SDS-PAGE

Clonality

monoclonal

Clone ID

7C8

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance(By similarity). Plays a role in the human tumorigenesis(PubMed:22748190).

Immunogen

neuron derived neurotrophic factor

Synonyms

CIR2, NENF, NEUDESIN, SCIRP10, SPUF, SPUF protein

Observed MW

18 kDa

Reactivity

Human, Mouse

Tested Application

ELISA, IHC, WB,IF

Recommended dilution

WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:50-1:500

Gene ID

29937

Research Area

Neuroscience