anti- NCOA6 antibody

Host

Rabbit

Uniprot ID

Q14686

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist-and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids(GR and ERs), retinoids(RARs and RXRs), thyroid hormone(TRs), vitamin D3(VDR) and prostanoids(PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

Immunogen

nuclear receptor coactivator 6

Synonyms

AIB3, KIAA0181, RAP250, TRBP

Observed MW

68 kDa ; 219 kDa ; 110 kDa

Reactivity

Human, Mouse

Tested Application

ELISA, IP

Recommended dilution

IP: 1:200-1:2000

Gene ID

23054

Research Area

Metabolism