anti- N-cadherin antibody

Host

Mouse

Uniprot ID

P19022

Form

liquid

Purification

Protein A+G purification

Purity

? 95% as determined by SDS-PAGE

Clonality

monoclonal

Clone ID

1G1

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density(By similarity).

Immunogen

cadherin 2, type 1, N-cadherin(neuronal)

Synonyms

Cadherin 2, CD325, CDH2, CDHN, CDw325, N cadherin, NCAD, N-cadherin, Neural cadherin

Observed MW

130 kDa

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, IHC, WB

Recommended dilution

WB: 1:1000-1:10000; IHC: 1:20-1:200

Gene ID

1000

Research Area

Signal Transduction, Cardiovascular, Immunology, Neuroscience, Stem Cells