anti- MYO9B antibody

Host

Rabbit

Uniprot ID

Q13459

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions(PubMed:9490638). Also acts as a GTPase activator for RHOA(PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA(PubMed:26529257).

Immunogen

myosin IXB

Synonyms

MYR5

Observed MW

230-250kd

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, WB, IP

Recommended dilution

WB: 1:500-1:2000; IP: 1:200-1:2000

Gene ID

4650

Research Area

Signal Transduction