anti- CDC14B antibody

Host

Rabbit

Uniprot ID

O60729

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome(APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.

Immunogen

CDC14 cell division cycle 14 homolog B(S. cerevisiae)

Synonyms

Observed MW

56 kDa

Reactivity

Human

Tested Application

ELISA, WB

Recommended dilution

WB: 1:500-1:2000

Gene ID

8555

Research Area

Cell Division and Proliferation, Metabolism