anti- CD59 antibody

Host

Rabbit

Uniprot ID

P13987

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Potent inhibitor of the complement membrane attack complex(MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.

Immunogen

CD59 molecule, complement regulatory protein

Synonyms

MIC11, MIN1, MIN2, MIN3, MSK21

Observed MW

18-20 kDa

Reactivity

Human

Tested Application

ELISA, WB, IHC, FC, IF

Recommended dilution

WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

Gene ID

966

Research Area

Stem Cells, Immunology, Signal Transduction