anti- CD44 antibody

Host

Mouse

Uniprot ID

P16070

Form

liquid

Purification

Protein A+G purification

Purity

? 95% as determined by SDS-PAGE

Clonality

monoclonal

Clone ID

7D6

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Receptor for hyaluronic acid(HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases(MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T(iTreg) cell stability and suppressive function(By similarity).

Immunogen

CD44 molecule(Indian blood group)

Synonyms

LHR, MDU2, MDU3, MIC4

Observed MW

80-95 kDa

Reactivity

Human

Tested Application

ELISA, WB, IHC, IF, FC

Recommended dilution

WB: 1：500-1：5000; IHC: 1：50-1：200; IF: 1：10-1：100

Gene ID

960

Research Area

Stem Cells, Immunology, Cardiovascular, Cancer