anti- CD3 epsilon antibody

Host

Mouse

Uniprot ID

P07766

Form

liquid

Purification

Protein A+G purification

Purity

? 95% as determined by SDS-PAGE

Clonality

monoclonal

Clone ID

20000

Isotype

IgG1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background

CD3 is a complex of proteins that directly associates with the T cell receptor (TCR). The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. The TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. TCR-mediated peptide-MHC recognition is transmitted to the CD3 complex, leading to the intracellular signal transduction. CD3 is considered to be a pan-T cell marker for detection of normal and neoplastic T cells. This anti-CD3 is a monoclonal antibody directed against the epsilon chain of human CD3 molecule.

Immunogen

CD3e molecule, epsilon (CD3-TCR complex)

Synonyms

CD3, CD3 epsilon, CD3E, CD3-epsilon, T3E, TCRE

Observed MW

23 kDa

Reactivity

Human

Tested Application

ELISA, WB, IHC, IF, FC

Recommended dilution

WB: 1:2000 - 1:20000; IHC: 1:1000 - 1:10000; IF: 1:50 - 500

Gene ID

916

Research Area

Cancer, Immunology, Signal Transduction