anti- CAMKK2 antibody

Host

Rabbit

Uniprot ID

Q96RR4

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase(AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals(By similarity). Seems to be involved in hippocampal activation of CREB1(By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.

Immunogen

calcium/calmodulin-dependent protein kinase kinase 2, beta

Synonyms

CAMKKB, KIAA0787

Observed MW

55-60 kDa

Reactivity

Human, Mouse

Tested Application

ELISA, WB, IF

Recommended dilution

WB: 1:500-1:2000; IF: 1:20-1:200

Gene ID

10645

Research Area

Neuroscience, Signal Transduction, Metabolism