anti- BUB3 antibody

Host

Rabbit

Uniprot ID

O43684

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule(K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome(APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.

Immunogen

budding uninhibited by benzimidazoles 3 homolog(yeast)

Synonyms

Observed MW

Reactivity

Human, Mouse, Rat

Tested Application

ELISA, IF

Recommended dilution

IF: 1:20-1:200

Gene ID

9184

Research Area

Cell Division and Proliferation