anti- BMI1 antibody

Host

Rabbit

Uniprot ID

P35226

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Component of a Polycomb group(PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Immunogen

BMI1 polycomb ring finger oncogene

Synonyms

BMI1, PCGF4, Polycomb complex protein BMI 1, RING finger protein 51, RNF51

Observed MW

43-45 kDa

Reactivity

Human, Mouse

Tested Application

ELISA, WB, IHC, IF, IP

Recommended dilution

WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Gene ID

648

Research Area

Epigenetics, Metabolism, Cancer, Developmental biology, Stem Cells, Cell Division and Proliferation