anti- BCL2L1 antibody

Host

Mouse

Uniprot ID

Q07817

Form

liquid

Purification

Protein A+G purification

Purity

? 95% as determined by SDS-PAGE

Clonality

monoclonal

Clone ID

2A9

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel(VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785). Isoform Bcl-X(S) promotes apoptosis.

Immunogen

BCL2-like 1

Synonyms

BCL2L, BCLX

Observed MW

35 kDa

Reactivity

Human

Tested Application

ELISA, WB, IHC, IF

Recommended dilution

WB: 1:2000-1:20000; IHC: 1:200-1:600; IF: 1:10-1:100

Gene ID

598

Research Area

Neuroscience, Cancer, Immunology, Cardiovascular