anti- BCL2 antibody

Host

Mouse

Uniprot ID

P10415

Form

liquid

Purification

Protein A+G purification

Purity

? 95% as determined by SDS-PAGE

Clonality

monoclonal

Clone ID

8A10

Isotype

IgG2a

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor(APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785).

Immunogen

B-cell CLL/lymphoma 2

Synonyms

Apoptosis regulator Bcl 2, B cell CLL/lymphoma 2, BCL2, Oncogene B cell leukemia 2

Observed MW

26 kDa

Reactivity

Human

Tested Application

ELISA, WB, IP, IHC

Recommended dilution

WB: 1:1000-1:10000; IP: 1:500-1:5000; IHC: 1:100-1:2000

Gene ID

596

Research Area

Neuroscience, Cancer, Immunology, Cardiovascular