anti- BAX antibody

Host

Rabbit

Uniprot ID

Q07812

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction(PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria(PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis(PMID: 8183579).

Immunogen

BCL2-associated X protein

Synonyms

BCL2L4,Apoptosis regulator BAX, BAX

Observed MW

21 kDa

Reactivity

Human, Mouse, Rat, Rabbit, Sheep

Tested Application

ELISA, WB, IHC, IP, FC

Recommended dilution

WB: 1:1000-1:10000; IP: 1:1000-1:10000; IHC: 1:20-1:200

Gene ID

581

Research Area

Neuroscience, Cancer, Developmental biology