anti- BAP1 antibody

Host

Rabbit

Uniprot ID

Q92560

Form

liquid

Purification

Immunogen affinity purified

Purity

>= 95%

Clonality

polyclonal

Clone ID

Isotype

IgG

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

Background

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119'(H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal(NLS), thereby protecting it from cytoplasmic sequestration(PubMed:24703950). Acts as a tumor suppressor.

Immunogen

BRCA1 associated protein-1(ubiquitin carboxy-terminal hydrolase)

Synonyms

BAP1, BRCA1 associated protein 1, Cerebral protein 6, HUCEP 13, hucep 6, KIAA0272, UCHL2

Observed MW

91 kDa

Reactivity

Human, Mouse

Tested Application

ELISA, WB

Recommended dilution

WB: 1:500-1:1000

Gene ID

8314

Research Area

Epigenetics, Metabolism